Anxiety
- Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug (PubMed)
- Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)
- Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients (PubMed)
- Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder (PubMed)
- Effects of cannabidiol (CBD) on regional cerebral blood flow (PubMed)
Alzheimer’s
- Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells (PubMed)
- Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression (PubMed)
- Cannabidiol: A promising drug for neurodegenerative disorders? (PubMed)
- Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement (PubMed)
- Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic (Pub Med)
Addiction
- Cannabidiol reduces cigarette consumption in tobacco smokers (PubMed)
- Cannabidiol inhibits the reward-facilitating effect of morphine (PubMed)
- Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances (PubMed)
- Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment (PubMed)
- Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity (PubMed)
- Cannabidiol for the treatment of cannabis withdrawal syndrome (PubMed)
AIDS
Arthritis
Atherosclerosis
Cancer
- Cannabidiol as potential anticancer drug (PubMed)
- Cannabidiol inhibits angiogenesis by multiple mechanisms (PubMed)
- Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1 (PubMed)
- Endocannabinoids in endocrine and related tumors (PubMed)
- A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells (PubMed)
- TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer (PubMed)
- Cannabis and Cannabinoids (PDQ®)Laboratory/Animal/Preclinical Studies(National Cancer Institute)
Lung Cancer
- Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C (PubMed)
- Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells (PubMed)
Prostate / Colon Cancer
- Towards the use of non-psychoactive cannabinoids for prostate cancer (PubMed)
- In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines (Scirp.org)
- Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent (PubMed)
- Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer (PubMed)
Breast Cancer
- Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma (PubMed)
- Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy (PubMed)
- Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis (PubMed)
- Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells (PubMed)
Brain Cancer
- Antitumor effects of cannabidiol, a non-psychoactive cannabinoid, on human glioma cell lines(PubMed)
- Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas (PubMed)
- Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor independent mechanism (PubMed)
- Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target (PubMed)
- Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents (PubMed)
- Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect (PubMed)
- Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme (PubMed)
- The Combination of Cannabidiol and Δ9-Tetrahydrocannabinol Enhances the Anticancer Effects of Radiation in an Orthotopic Murine Glioma Model
Leukemia
- Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression (PubMed)
- Cannabidiol-Induced Apoptosis in Human Leukemia Cells (PubMed)
Skin Cancer
Kaposi Sarcoma
Crohn’s & Stomach Problems
- Cannabidiol in inflammatory bowel diseases: a brief overview (PubMed)
- Cannabis finds its way into treatment of Crohn’s disease (PubMed)
- Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (PubMed)
- Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis (PubMed)
- Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice (PubMed)
- Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis (O’Shaughnessy’s)
Depression
- Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa (PubMed)
- The endocannabinoid system and the treatment of mood and anxiety disorders (PubMed)
- Antidepressant-Like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors (PubMed)
- Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants (PubMed)
- The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants (PubMed)
Diabetes
- Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy (PubMed)
- Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation (PubMed)
- The endocannabinoid system in obesity and type 2 diabetes (PubMed)
- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes (PubMed)
- Cannabinoid-mediated modulation of neuropathic pain and microglial accumulation in a model of murine type I diabetic peripheral neuropathic pain (PubMed)
Epilepsy/Seizure
- Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment resistant epilepsy (PubMed)
- The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability (ACS Publications)
- Chronic administration of cannabidiol to healthy volunteers and epileptic patients (PubMed)
- Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders (PubMed)
- Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures (PubMed)
- Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo (PubMed)
- Hypnotic and anti-epileptic effects of cannabidiol (PubMed)
- CBD for children with Dravet’s and intractable seizures (Video)
Heart Disease
- Is the cardiovascular system a therapeutic target for cannabidiol? (PubMed)
- Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion (PubMed)
- Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy (PubMed)
- The Effect of Cannabidiol on Ischemia/Reperfusion-Induced Ventricular Arrhythmias: The Role of Adenosine A1 Receptors (PubMed)
- Cannabidiol, a non-psychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury (PubMed)
- Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension (PubMed)
- Oleamide: A fatty acid amide signaling molecule in the cardiovascular system? (PubMed)
Huntington’s
- Cannabinoids: Novel medicines for the treatment of Huntington’s disease (PubMed)
- Prospects for cannabinoid therapies in basal ganglia disorders (PubMed)
Inflammation
- Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress (PubMed)
- The endocannabinoid system: an emerging key player in inflammation (PubMed)
- Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice (PubMed)
- Cannabinoids, endocannabinoids, and related analogs in inflammation (PubMed)
- Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor (PubMed)
- Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors (PubMed)
- Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation (PubMed)
- Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement (PubMed)
- Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption (PubMed)
- Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death (PubMed)
- Cannabinoids in clinical practice (PubMed)
Irritable Bowel
- Cannabidiol in inflammatory bowel diseases: A brief overview (PubMed)
- Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis (PubMed)
- Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions? (PubMed)
- Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology) (ScienceDirect)
Kidney Disease
Liver Disease
- The endocannabinoid system and liver diseases (PubMed)
- Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis (PubMed)
- Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats (PubMed)
- Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol (PubMed)
- Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice (PubMed)
Metabolic Syndrome
Migraine
Mood Disorders
- Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders (PubMed)
- The endocannabinoid system and the treatment of mood and anxiety disorders (PubMed)
- The endocannabinoid system and psychiatric disorders (PubMed)
- The endocannabinoid system in the regulation of emotions throughout lifespan: A discussion on therapeutic perspectives (PubMed)
- Effects of cannabidiol (CBD) on regional cerebral blood flow (PubMed)
Motion Sickness
MS / Multiple Sclerosis
- Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors (PubMed)
- Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis (PubMed)
Nausea
- Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behavior via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus (PubMed)
- Regulation of nausea and vomiting by cannabinoids (PubMed)
Neurodegeneration
- Cannabidiol: A promising drug for neurodegenerative disorders? (PubMed)
- Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid? (PubMed)
- Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection (Pub Med)
Obesity
- The endocannabinoid system in obesity and type 2 diabetes (PubMed)
- Role of the endocannabinoid system in abdominal obesity and the implications for cardiovascular risk (PubMed)
- Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes (PubMed)
Osteoporosis
- Cannabinoid receptors as target for treatment of osteoporosis: A tale of two therapies (PubMed)
- Cannabinoids and bone: Friend or foe? (PubMed)
- Cannabinoid receptor type 1 protects against age-related osteoporosis by regulating osteoblast and adipocyte differentiation in marrow stromal cells (PubMed)
- The endovanilloid/endocannabinoid system: A new potential target for osteoporosis therapy (PubMed)
- The endovanilloid/endocannabinoid system in human osteoclasts: Possible involvement in bone formation and resorption (PubMed)
- Cannabinoid receptors and the regulation of bone mass (PubMed)
Parkinson’s
- Prospects for cannabinoid therapies in basal ganglia disorders (PubMed)
- Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease (PubMed)
- Cannabidiol can improve complex sleep-related behaviors associated with rapid eye movement sleep behavior disorder in Parkinson’s disease patients: a case series (PubMed)
- Cannabidiol for the treatment of psychosis in Parkinson’s disease (PubMed)
- Effects of cannabidiol in the treatment of patients with Parkinson’s disease: an exploratory double-blind trial. (PubMed 2014)
- Dorsolateral Prefrontal Cortex N-Acetylaspartate/Total Creatine (NAA/tCr) Loss in Male Recreational Cannabis Users (Research Gate/PubMed 2007)
- Cannabidiol for the treatment of psychosis in Parkinson’s disease. (PubMed)
Prion/Mad Cow disease
PTSD
- Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors (PubMed)
- Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis (PubMed)
- Cannabinoid modulation of fear extinction brain circuits: A novel target to advance anxiety treatment (PubMed)
- The endocannabinoid system and extinction learning (PubMed)
- Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit (PubMed)
- The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system (PubMed)
Rheumatism
Schizophrenia
- Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug (PubMed)
- Cannabidiol as a potential treatment for psychosis (PubMed)
- Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia (PubMed)
- Medical use of cannabis. Cannabidiol: A new light for schizophrenia? (PubMed)
- A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation (PubMed)
- Cannabinoids and schizophrenia: Therapeutic prospects (PubMed)
- Antipsychotic-like effects of cannabidiol and rimonabant: Systematic review of animal and human studies (PubMed)
- Cannabidiol monotherapy for treatment-resistant schizophrenia (PubMed)
- Cannabis with high cannabidiol content is associated with fewer psychotic experiences (PubMed)
Skin conditions
- Cannabidiol exerts sebostatic and anti-inflammatory effects on human sebocytes (PubMed)
- The endocannabinoid system of the skin in health and disease: Novel perspectives and therapeutic opportunities (PubMed)
- Epigenetic control of skin differentiation genes by phytocannabinoids (PubMed)
- A novel control of human keratin expression: cannabinoid receptor 1-mediated signaling down-regulates the expression of keratins K6 and K16 in human keratinocytes in vitro and in situ (PubMed)
- Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid1 (PubMed)
- Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus (PubMed)
Sleep disorders
- The non-psychoactive Cannabis constituent cannabidiol is a wake-inducing agent (PubMed)
- Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, a cannabis based medicine (PubMed)
Stress
- Endogenous cannabinoid signaling is essential for stress adaptation (PubMed)
- Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders (PubMed)
- Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress (PubMed)
- Stress regulates endocannabinoid-CB1 receptor signaling (PubMed)
- Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus (Pub Med)
- Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance (PubMed)